Erin Baker had four goals and three assists to lead Misericordia while Olivia Garcia added four goals and an assist.
Lindsay McKim scored three goals and Ashley Hobbs added two scores.
Allie Elmes had a goal, two assists and a team-high six ground balls.
Katie McLoughlin made five saves to earn the win.
Brianna Ladner had six draw controls, three ground balls and scored her first goal of the season.
Taylor Simeone had four ground balls and three caused turnovers and Garcia added four ground balls and two caused turnovers.
Wilkes had the first scoring opportunity less than two minutes into the game, but Baker blocked a free position shot.
Hobbs put the Cougars in front at 22:07 when she took a feed from Elmes, spun around a defender and placed a shot inside the right post.
Misericordia had a goal waved off and bounced a shot off each post over the next three minutes.
McKim made it 2-0 when she bounced a shot inside the left post off a re-start with 16:42 left in the first half.
Wilkes converted an MU turnover behind their own goal into an empty-net goal to cut the deficit in half at 14:19.
After a Hobbs shot caromed off the left post, Wilkes tied the score with 11:50 to go in the half.
The Cougars took the lead for good when McKim buried a free position shot in the upper right corner and Garcia bounced in a tough-angle shot from the left baseline to make it 4-2 with 9:37 remaining.
Baker tallied twice in a two-minute span to put MU up, 6-2.
After a Wilkes goal, Mulvey answered with a free position goal for a 7-3 lead at halftime.
Garcia scooped up a ground ball in front of the net and converted for an 8-3 lead early in the second half.
Baker and Garcia combined for four goals in a seven-minute span as the Cougars stretched the lead to 13-4 with 13:31 to play.
Misericordia will travel to FDU-Florham, Saturday.